the l-selectin phe206leu gene polymorphism is not associated with visceral leishmaniasis

نویسندگان

khosro sardarian

mohammad abasi

ghasem solgi

mehrdad hajilooi

چکیده

background: previous studies revealed that selectins play key roles in homing of immune cells to inflamed tissues and lymphatic organs. l-selectins are expressed on immune cells and interact with p and e selectins to homing to the tissues, hence, the polymorphisms within the gene of l-selectins may are associated with alteration in its expression. thus, the current cross-sectional analytical study has been designed to investigate the polymorphisms within l-selectin gene and their relation with visceral leishmaniasis (vl). methods: this study was performed on 194 samples during 2004-2012.the pcr-ssp and immunoflorescence techniques were used to evaluate the l-selectins polymorphism and anti- leishmania antibody titration, respectively, in 56, 74 and 64 seropositive vl patients (group 1) , seropositive healthy controls (group 2) and seronegative healthy controls ( group 3 ) . results: the results showed that the genotypes ( p =0.711) and alleles ( p =0.679) within l-selectins gene (a/c) was not differ between groups. our results also demonstrated that the genotypes within l-selectins in group 1 ( p =0.807) and 2 ( p =0.441) were not associated with the titration of anti-leishmania antibody. conclusions: the results identified that the polymorphisms within l-selectins gene were not associated with vl and it may be concluded that these genotypes and alleles are unable to affect immune responses in vl patients.

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عنوان ژورنال:
journal of research in health sciences

جلد ۱۴، شماره ۳، صفحات ۲۱۸-۰

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